Genome-wide association identifies multiple ulcerative colitis susceptibility loci

Dermot P B McGovern,Agnès Gardet,Leif Törkvist,Philippe Goyette,Jonah Essers, Kent D Taylor,Benjamin M Neale,Rick T H Ong,Caroline Lagacé,Chun Li,Todd Green,Christine R Stevens,Claudine Beauchamp,Phillip R Fleshner,Marie Carlson, Mauro D'Amato,Jonas Halfvarson,Martin L Hibberd,Mikael Lördal,Leonid Padyukov,Angelo Andriulli,Elisabetta Colombo,Anna Latiano,Orazio Palmieri,Edmond-Jean Bernard,Colette Deslandres,Daan W Hommes,Dirk J de Jong,Pieter C Stokkers,Rinse K Weersma,Yashoda Sharma,Mark S Silverberg,Judy H Cho,Jing Wu,Kathryn Roeder,Steven R Brant,L Phillip Schumm,Richard H Duerr,Marla C Dubinsky,Nicole L Glazer,Talin Haritunians,Andy Ippoliti,Gil Y Melmed,David S Siscovick,Eric A Vasiliauskas,Stephan R Targan,Vito Annese,Cisca Wijmenga,Sven Pettersson, Jerome I Rotter,Ramnik J Xavier,Mark J Daly,John D Rioux,Mark Seielstad

Nature Genetics（2010）

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摘要

Mark Seielstad and colleagues report results of a large genome-wide association and replication study of ulcerative colitis. The work identifies several new risk loci for this disease and provides further insight into the shared pathogenesis of ulcerative colitis and Crohn's disease.

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关键词

Genetic predisposition to disease,Genome-wide association studies,Ulcerative colitis,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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