Survival rate of colorectal cancer and its effective factors in Iran

Objective: Colorectal cancer is one of the most common cancers in Iran. Regarding the prevalence of this cancer and its mortality and morbidity, in this study, 5 Year Survival Rate and its Effective Factors of patients with colorectal cancer investigated. Material and Methods: This study was conducted using retrospective cohort method. All patients diagnosed with colorectal cancer during the 2006-2011 years in Hamadan Imam Khomeini Clinic of Hematology and Oncology and Mahdieh Oncology Center were studied. Require data were extracted from their medical records. To obtain information about patients, telephone calls were made. The data were analyzed by SPPS version 16 and assessment of survival rates was conducted using Kaplan-Meier methods and Cox regression method. Results: A total number of 108 patients with colorectal cancer were included in the study. The status of 74 patients was determined at the end of the study by follow up call . The one, two, three, four and five overall were 77, 66, 50, 45 and 42%, respectively. The median overall survival was 46.8 months (1.3-135.6 months). Cox regression analysis showed that Metastatic tumor (p value= 0.001), lymphatic involvement (p value= 0.043) and being associated with underlying disease (p value= 0.025) was accompanied by increased risk. Multivariate cox regression test showed that metastasis was associated with increasing risk of death significantly (HR=2.83, p value= 0.013). Conclusion: According to the findings of the study, early screening for increasing the survival rate is recommended for people with greater risk.