Studies on cell lineage of metaphyseal bone in repleted scorbutic guinea pigs
Calcified Tissue International(1983)
Abstract
Summary Young weanling guinea piglets were placed on a diet deficient only in vitamin C. When they reached a state of severe scorbutus,
they were given vitamin C and the morphological differentiation of various mesenchymal cells in the proximal end of the tibia
was followed over 7 days. The altering metaphyseal cellular pattern is recorded descriptively as well as quantitatively. Levels
of mesenchymal cells, preosteoblasts, osteoblasts, and osteocytes remained relatively steady for 24h. However, by 48 h there
was a precipitous decline of mesenchymal cells with a concomitant rise in recognizable osteogenic cells; this change continued
until the 7th day of repletion. At this time, with the exception of the preosteoblasts, the cellular population had returned
to about the level in the control animals. Osteoclastic and endothelial cellular movements fluctuated widely during the period
of repletion under examination. These results support the concept of separate lines of differentiation for osteoclasts and
osteoblasts in the postnatal animal. Moreover, mesenchymal cells appear to be precursors of osteogenic cells.
MoreTranslated text
Key words
bone cells -- histogenesis -- scurvy -- vitamin c.,Bone cells,Histogenesis,Scurvy,Vitamin C
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