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Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.

Madhavi Pannala,Sunil Kher,Norma Wilson,John Gaudette,Ila Sircar,Shao-Hui Zhang,Alexei Bakhirev,Guang Yang,Phoebe Yuen,Frank Gorcsan,Naoki Sakurai,Miguel Barbosa,Jie-Fei Cheng

Bioorganic & Medicinal Chemistry Letters（2007）

Cited 56|Views20
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Abstract
A series of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles have been synthesized and tested for EGFR inhibition. Compounds 29 and 30 showed excellent enzymatic and cellular activities against EGFR.
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EGFR inhibitor,Quinoline-3-carbonitrile
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