慢性阻塞性肺疾病急性加重患者血清降钙素原变化的临床意义
Chinese Journal of Clinical Medicine(2012)
Abstract
目的:探讨降钙素原(procalcitonin,PCT)对慢性阻塞性肺疾病急性加重(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者应用抗生素的临床意义.方法:选择细菌感染所致AECOPD患者90例,分别于抗生素治疗前和治疗后10~14 d检测患者血清PCT、白细胞计数(white blood cell,WBC)、C反应性蛋白(C-reactive protein,CRP)和血沉(erythrocyte sedimentation rate,ESR).结果:抗生素治疗后,PCT、WBC、CRP、ESR均显著下降.其中PCT≥0.25ng/mL者,治疗前为88例(97.8%),治疗后为0例(0%),P<0.05;WBC≥10×109/L者,治疗前为65例(72.2%),治疗后下降至8例(8.9%),P<0.05;ESR≥20mm/1 h者,治疗前为88例(97.8%),治疗后下降至20例(22.2%),P<0.05;CRP≥10 mg/L者治疗前为86例(91.1%),治疗后下降至14例(15.6%),P<0.05.结论:PCT检测可作为观察AECOPD的细菌感染控制的指标之一.
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Key words
Bacterial infection,Procalcitonin,Acute exacerbation,Chronic obstructive pulmonary disease
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