Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT2C agonists for the treatment of metabolic disorders

Heather Tye,Stephan G. Mueller,Juergen Prestle,Stefan Scheuerer,Marcus Schindler,Bernd Nosse,Natacha Prevost,Christopher J. Brown,Alexander Heifetz,Clemens Moeller,Anna Pedret-Dunn,Mark Whittaker

Bioorganic & Medicinal Chemistry Letters（2011）

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摘要

A new class of potent and selective 5-HT2C agonists for the treatment of metabolic disorders is described. Optimization of selectivity, permeability and hERG interaction is discussed.

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关键词

5HT2C agonist,Metabolic disease,hERG inhbiiton

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