Depolymerization of sodium hyaluronate during freeze drying
International Journal of Biological Macromolecules(1983)
Abstract
Freeze drying of sodium hyaluronate causes free radical induced depolymerization of the polysaccharide which may be inhibited by such free radical scanvengers as Cl−, I−, alcohols and sugars. The free radical process is probably induced by mechanical stress factors. Such effects are important in freeze drying of all biopolymer solutions.
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Key words
Polysaccharides,hyaluronate,freeze-drying,depolymerization,free radicals
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