甲胎蛋白异质体在唐氏综合征筛查中的价值
Chinese Journal of Birth Health & Heredity(2012)
Abstract
目的评价甲胎蛋白(AFP)异质体在唐氏综合征筛查的作用。方法留取孕中期15例经确诊为唐氏综合征孕妇及50例正常孕妇的血清,运用放射免疫法及凝集素亲和电泳免疫印迹法分别测定血中AFP含量及AFP异质体(AFP-L2/3)的比率,评估AFP-L2/3比率与唐氏综合征的相关性。结果唐氏综合征孕妇血清中AFP的含量低于正常孕妇(39.3±17.5ng/ml vs54.5±16.5ng/ml,P<0.05),而AFP-L2/3的百分比高于正常孕妇血清中AFP-L2/3的百分比(41.8±6.9%vs35.5±4.4%,P<0.05)。结论甲胎蛋白异质体的百分比可作为唐氏综合征筛查的血清学指标之一。
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Key words
Screening,Variants of alpha-fetoprotein,Down′s syndrome
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