Radiolabeling procedure, quality control and stability of 99mTc-labeled chondroitin sulfate: a new approach of targeting osteoarthritis.
Applied Radiation and Isotopes(2008)
摘要
Chondroitin sulfate (CS) is an endogenous component of cartilage which could determine osteoarthritis after radiolabeling. Radiolabeling was performed by 99mTcO4−/tin method. We found that pH is a limiting factor. At pH 6.2 in 0.05M Na acetate buffer 32.8% colloid was formed, at pH 5.0 in 0.5M Na acetate, in our methodology only 4.7% colloid. The tracer was highly stable. We conclude that 99mTcCS could be a promising imaging agent of osteoarthritis due to simple radiolabeling and high stability.
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关键词
99mTc-chondroitin sulfate,Osteoarthritis,Radiolabeling,Radiochemical purity,Stability,Radiopharmaceuticals
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