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Renal contribution TC sympathetic overactivity in patients with cirrhosis

Journal of Hepatology(1990)

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摘要
The purpose of this study was to estimate the relative contribution of the kidneys to overall sympathetic activity in a large series of cirrhotic patients. In 55 patients with cirrhosis, plasma norepinephrine concentrations (PNCI were measured by HPLC with electrochemical detection in the right renal vein and in the pulmonary artery. Following values were calculated: plasWl norepinrphtine renal outflow = PNC in the right renal vein x renal plasma flow (PAH clearance and extraction method); total plasma norepinephrine flow = PNC in the pulmonary artery Y cardiac output x (1-M.). Results are mean + SE. PNC was significantly higher in the right renal vein than in the pulmonary artery (803 + 54 and 608 f 47 pghl. respectively). Total phsma norepinephrine flow was 3073 +271. Plasma norepinephrine renal outflow was 480 + 50. The ratio between these two values ranged from 3 to 491. Total plasma norepinephrine flow was significantly correlated with renal norepinephrine outflow (r-=0.663; p
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关键词
renal contribution tc,sympathetic overactivity,cirrhosis
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