Current challenges in implementing cell-derived influenza vaccines: Implications for production and regulation, July 2007, NIBSC, Potters Bar, UK

Philip D. Minor,Othmar G. Engelhardt,John M. Wood,James S. Robertson, Simone Blayer, Tony Colegate, Luc Fabry, Jacco G.M. Heldens,Yoichiro Kino,Otfried Kistner, Ronald Kompier, Keiichi Makizumi,Jeroen Medema, Shigetaka Mimori,David Ryan,Richard Schwartz, Jonathan S.B. Smith, Keishin Sugawara,Heidi Trusheim,Theodore F. Tsai

Vaccine(2009)

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摘要
A meeting was held at NIBSC, UK in July 2007 to discuss the implications of progress in the use of cell culture systems for the manufacture of vaccines against influenza. Issues discussed included the effect of using eggs and different cell types in strain selection, development of seed viruses to be used in production and the nature of the reagents to be used in determining vaccine potency. Future studies to progress the field were reviewed.
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关键词
Influenza vaccine manufacture,Cell substrates,Reagent development,Strain selection
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