40 mg阿托伐他汀短期内对ACS患者血清炎症因子的影响
Journal of Clinical Research(2008)
Abstract
[目的]探讨短期内使用阿托伐他汀强化降脂对急性冠脉综合征(ACS)患者血清高敏C反应蛋白(hs-CRP)及白细胞介素-6 (IL-6)的影响,以了解其对ACS炎症抑制和斑块稳定作用.[方法]70例ACS患者抽血检查后随机分为常规组35例,阿托伐他汀组35例,常规组常规治疗,不用降脂药物,阿托伐他汀组予阿托伐他汀40 mg/d,口服.所有患者药物治疗前和治疗后d3及PCI术后48 h检测血脂及hs-CRP、IL-6等指标.[结果]阿托伐他汀组hs-CRP、IL-6两项指标明显降低(P<0.05),而常规组无明显变化.PCI术后48 h,两指标浓度均有明显升高,但阿托伐他汀组升高程度明显低于常规组(P<0.05).[结论]阿托伐他汀能迅速降低ACS患者的血清炎症因子,具有抑制炎症和斑块稳定作用.
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Key words
coronary disease/DT,antilipemic agents/AD,chemokines/BL
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