131 JX-594, A TARGETED MULTI-MECHANISTIC ONCOLYTIC POXVIRUS, IS WELL-TOLERATED AND EXHIBITS ANTI-TUMOR ACTIVITY IN PATIENTS WITH PRIMARY LIVER CANCER AND LIVER METASTASES

PRESENTATIONSliver apoptosis or steatosis and were completely protected from hepatocarcinogenesis, whereas 100% of NEMO Dhepa mice developed hepatocellular carcinoma.Conclusions: Ablation of Casp8 protects from receptor-mediated apoptosis but may trigger RIP-dependent programmed necrosis in an inflammatory environment.However, inhibition of Casp8 has beneficial effects in chronic liver injury with dominant liver apoptosis as it protects from hepatocarcinogenesis.