Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics.

Belen Vaz,Sabine Möcklinghoff,Simon Folkertsma,Scott Lusher,Jacob de Vlieg,Luc Brunsveld

CHEMICAL COMMUNICATIONS（2009）

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摘要

Insertion of 3 to 4 mutations, based on in silico modelling, in a diverse set of natural miniproteins generates potent androgen receptor (AR) binders and a clear insight into the structure-activity relationship of such coactivator mimics concerning helix length.

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关键词

androgen receptor,structure activity relationship

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