CORRELATION OF RENAL RESISTIVE INDEX, TUMOUR NECROSIS alpha AND INTERLEUKIN 10 WITH HYPERTENSIVE RENAL DAMAGE

Objective To investigate the changes of renal resistive index(RRI) and the serum levels of necrosis alpha(TNF-α) and interleukin 10(IL-10) in patients with hypertensive renal damage,whereby to explore the correlation of RRI,TNF-α and IL-10 with the hypertensive renal damage.Methods Seventy three patients with primary hypertension were divided into two groups according to their urinary albumin excretion rate:simple hypertension group(n=37),hypertensive renal damage group(n=36).RRI was measured using Doppler ultrasonography,serum TNF-α and IL-10 using radioimmune assay.Thirty normotensive healthy persons were selected as normotensive control group.Results RRI and TNF-α in the hypertension group were higher than those in the normotensive control group(P<0.05),with RRI and TNF-α in the hypertensive renal damage group being higher than those in the simple hypertension group(P<0.05) and IL-10 in the hypertension group was lower than that of normotensive control group(P<0.05),IL-10 in the hypertensive renal damage group was also lower than that of simple hypertension group(P<0.05).There was statistical significance in RRI,TNF-α and IL-10 between the groups(P<0.05).RRI,TNF-α and IL-10 in the hypertension group were associated with the urinary albumin excretion rate(r=0.801,P<0.01;r=0.703,P<0.01;r=-0.613,P<0.01).RRI was positively conelated with TNF-α(r=0.609,P<0.001),negatively correlated with IL-10(r=-0.533,P<0.01),but not correlated with the level of blood pressure.Conclusion RRI is remarkably increased in patients with hypertensive renal damage,whereby can be used as a parameter in evaluating hypertensive renal damage.TNF-α is increased and IL-10 decreased significantly in patients with hypertensive renal damage,indicating that the imbalanced cytokine network may play a role in the pathological mechanisms of hypertensive renal damage.