湖南地区汉族人群Per2基因多态性与睡眠癫痫的相关性研究
Journal of International Neurology and Neurosurgery(2012)
Abstract
目的探讨Per2C111G基因多态性与中国湖南地区汉族人群睡眠癫痫的关系。方法选取湖南地区汉族癫痫患者300例及健康对照组100例,癫痫患者按好发时间分为觉醒癫痫组、不定期癫痫组、睡眠癫痫组。采用聚合酶链反应(PCR)和基因测序方法检测Per2基因C111G位点的多态性。结果湖南地区汉族人群中,Per2基因C111G多态位点的基因型频率分别为:CC型87.0%、CG型13.0%、GG型0.0%,等位基因C和G频率分别为93.5%和6.5%。癫痫组和对照组间基因型及等位基因型频率差异无统计学意义(P>0.05)。3个癫痫亚组间基因型及等位基因型频率差异亦无统计学意义(P>0.05)。结论 Per2基因C111G位点多态性可能与湖南地区汉族人群睡眠癫痫无关。
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Key words
gene polymorphisms,Per2 gene,sleep-related epilepsy
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