Invistagation of antitumor efffect of internal Irradiation of Interventional Radionuclide ~(188)Re in Thermosensitive Chitosan on Mouse Transplanted Tumor H_(22)

Objectives To study the inhibitory activity of internal irradiation of interventional radionuclide 188Re in thermosensitive chitosan on mouse transplanted tumor H22(liver cancer).Method The tumor-bearing mice were divided into 7 groups randomly,including model control,188 Re(0.1mCi) group,188 Re-S(0.1mCi) group,188 Re + CS(0.1mCi) group,188 Re + CS(0.2mCi)group,188 Re-S + CS 0.1mCi)and188 Re-S + CS(0.2mCi)group.The mice tumor was injected with corresponding reagent respectively,and the inhibitoy rate of tumor was observed after administrated.Results The growth of tumors in 188 Re + CS group and 188 Re-S + CS group was slowed.the tumor inhibitory rate reached the highest level after 6 days therapy,which respectively was 67.35% and 67.81%.Conclusions Internal irradiation of interventional radionuclide 188 Re in thermosensitive chitosan had the effect of inhibitory mice liver cancer.