丁香酚注射液的含量测定和安全性试验
Hubei Agricultural Sciences(2006)
Abstract
采用紫外分光光度法测定丁香酚注射液的含量,并选用小鼠、豚鼠、家兔进行了腹腔注射急性毒性试验、刺激性与过敏性试验、溶血试验和热源检查。结果表明,丁香酚在波长286.0 nm,20~98μg.mL-1范围内浓度与吸收度有良好的线性关系,其回收率为96.8%,RSD是1.3%;安全性试验证明丁香酚注射液毒性小、无刺激性、无溶血现象、无过敏反应、无致热源。因此,采用紫外分光光度法测定丁香酚注射液的方法可靠,含量稳定,简单准确,安全检查符合药典规定,为临床研究提供了可靠依据。
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Key words
Ultravoilet spectrometry,safety test,Eugenol injection
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