On-Silicon Neural Activity Monitoring and Time-Frequency Analysis for Early Detection of Epileptic Seizures

We present an architecture and very-large-scale integration (VLSI) implementation of a microsystem for neural activity monitoring and time-frequency analysis. The key functional blocks of the microsystem, the integrated neural interface and the wavelet transform processor, have been prototyped in a 0.35-m standard complementary metal- oxide-semiconductor (CMOS) technology. Its utility is vali- dated in autonomous early detection of epileptic seizures in an in vitro epilepsy model of recurrent spontaneous seizures in mouse hippocampal brain slices.