Interaction of enterohemorrhagic Escherichia coli O157:H7 with mouse intestinal mucosa: EHEC O157:H7 in a mouse ileal loop model
FEMS MICROBIOLOGY LETTERS(2008)
摘要
In this study, we used mouse ileal loops to investigate the interaction of enterohemorrhagic Escherichia coli (EHEC) O157:H7 with the mouse intestinal mucosa. With a dose of 10(9) and 3 h incubation, EHEC O157 was detected in the lumen and to a lesser extent associated with the epithelium. Typical attaching and effacing (A/E) lesions were seen, albeit infrequently. While the effector protein Tir was essential for A/E lesion formation, the bacterial type III secretion system adaptor protein TccP was dispensable. These results suggest that A/E lesions on mouse intestinal mucosa can be formed independently of robust actin polymerization.
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关键词
EHEC O157 : H7,colonization,type III secretion system
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