Nitric oxide application during superimposed high-frequency jet-ventilation in patients with ARDS

Inhaled nitric oxide (NO) reduces pulmonary hypertension in severe ARDS and improves arterial oxygenation by redistributing blood flow to areas with a normal ventilation/perfusion ratio [1]. As high peak inspiratory pressure (PIP) may contribute to pulmonary damage ventilatory strategies like high-frequency (HF) ventilation search to minimize PIP. This study was designed to evaluate the combined benefits of superimposed high-frequency jet-ventilation (SHFJV), a new HF jet-ventilation technique, with addition of inhalational NO.