4-Chloro-3-(trifluoroacetyl)coumarin as a novel building block for the synthesis of 7-(trifluoromethyl)-6H-chromeno[4,3-b]quinolin-6-ones

Viktor O. Iaroshenko,Sajid Ali,Tariq Mahmood Babar,Sergii Dudkin,Satenik Mkrtchyan,Nasim Hasan Rama,Alexander Villinger,Peter Langer

Tetrahedron Letters（2011）

引用 32|浏览8

暂无评分

摘要

4-Chloro-3-(trifluoroacetyl)coumarin was synthesized for the first time via direct TMSCl-mediated acylation of 4-hydroxycoumarin with TFAA followed by the treatment with POCl3. The reaction of 4-chloro-3-(trifluoroacetyl)coumarin with commercially available anilines is a two-step method, which affords a set of 7-(trifluoromethyl)-6H-chromeno[4,3-b]quinolin-6-ones in good to excellent yields.

查看译文

关键词

Cyclization,Coumarins,Anilines,Heterocycles,Fluorine,Chromeno[4,3-b]quinolines

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要