Nerve growth factor selectively decreases activity-dependent conduction slowing in mechano-insensitive C-nociceptors.

Intracutaneous nerve growth factor reduces the activity-dependent slowing of conduction of the mechano-insensitive C-fibers. This long-term change of axonal characteristics might contribute to hyperalgesia. Parts of this study have been published in abstract form (Obreja et al., Society for Neuroscience Meeting, 2008, Washington, 668.5).