Imatinib in the Treatment of Nephrogenic Systemic Fibrosis

Nephrogenic systemic fibrosis is a disabling progressive condition that is being reported with increased frequency in patients with kidney disease. Treatment is extremely limited and largely supportive. We report a case of severe nephrogenic systemic fibrosis in a dialysis patient exposed to multiple doses of gadolinium who improved clinically and histologically with treatment with imatinib. Am J Kidney Dis 53:129-132. (C) 2008 by the National Kidney Foundation, Inc.