Novel carbazole derivatives as NPY Y1 antagonists

Colin P. Leslie,Romano Di Fabio,Francesca Bonetti,Manuela Borriello,Simone Braggio,Giovanna Dal Forno,Daniele Donati,Alessandro Falchi,Damiano Ghirlanda,Riccardo Giovannini,Francesca Pavone,Angelo Pecunioso,Giorgio Pentassuglia,Domenica A. Pizzi,Giovanna Rumboldt,Luigi Stasi

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

A series of carbazoles showing antagonist activity at the NPY Y1 receptor were prepared and characterised. Compound 13 combines potent activity with good brain penetration and modest bioavailability.

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关键词

Neuropeptide Y,NPY Y1 antagonist,CNS,Obesity

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