EGF受体配基N2S2-Quinazoline的合成

Jian-kang ZHANG,Xing-qin ZHOU,Xiao-feng QIN,Xi-jie XU,Mei-fen ZOU

Chemical Reagents（2012）

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Abstract

以6-硝基喹唑啉酮为原料,经过氯化亚砜氯化,间碘苯胺连接,氯化亚锡还原,制得6-氨基-4-[(3-碘苯基)氨基]-喹唑啉,再与氯乙酰氯反应,二硫二氮缩合连接,最后与醋酸汞硫化氢反应脱巯基保护基得到标记前体N-[ [4-(3-碘苯基)氨基]-喹唑啉-6-基]-2-[N-(2-巯基乙基)-N-[ [N-(2-巯基乙基)氨基]甲酰甲基]]乙酰胺,主要产物得到核磁和质谱表征,总收率2.5％.

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Key words

bis(aminoethanethiol) analog,quinazoline,synthesis,EGF receptor

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