Correlation of Morphologic MRI Features with Expression of Estrogen Receptor,Progesterone Receptor,CerbB-2 and Ki-67 in Breast Cancer

Objective To investigate the correlation of morphological MRI features with the expression of estrogen receptor(ER),progesterone receptor(PR),CerbB-2 and Ki-67 in breast cancer.Methods MRI was performed in 18 patients with primary breast cancer(20 foci,2 patients had foci in bilateral breasts),and morphological features of breast cancer were analyzed.The expression of ER,PR,CerbB-2 and Ki-67 in breast cancer was measured by ElivisionTMplus immunohistochemistry after operation.Results Among the 18 patients,MRI showed peculated margin in 14(70%),ring-enhancement in 12(60%) and lobulation in 10(50%).The lobulation was positively correlated with Ki-67 expression(P=0.035),but had no correlation with the expression of ER,PR and CerbB-2.Ring-enhancement and speculated margin did not show correlation with the expression of ER,PR,CerbB-2 and Ki-67.Conclusion There is a positive correlation between the lobulation and Ki-67 expression,suggesting that breast cancer with lobulation has a higher proliferative activity.Ring-enhancement and speculated margin have no correlation with the invasiveness,degree of malignancy and prognosis of breast cancer,suggesting that ring-enhancement and speculated margin have no definite significance in guiding the therapy of breast cancer.