Synthesis and contractile of new acetylenic and allenic analogues of leukotrienes C4 and D4: Importance of the Z-11, 12 double bond

J.P. Lellouche,F. Aubert,J.P. Beaucourt,E. Rechencq,G. Niel,J.P. Girard,J.C. Rossi,M. Boucard

Prostaglandins（1989）

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摘要

The (5S,6R) isomers of new acetylenic and allenic analogues of leukotrienes C4 and D4 were synthesized for comparative pharmacological studies on intestinal smooth muscle preparations.

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leukotrienes c4,allenic analogues,synthesis,double bond

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