357: Association between first trimester placental volume, uterine artery resistance index, PAPP-A and total β-HCG and birthweight in a low risk population

ObjectiveA number of first trimester ultrasound and maternal serum markers have been proposed to predict intrauterine growth restriction (IUGR). The goal of this study was to determine if placental volume, mean uterine artery resistance index (UtA RI), PAPP-A and total β-hCG (hCG) are associated with birth weight (BWt) in a low risk population.Study DesignThree-dimensional placental volume, UtA RI and maternal serum PAPP-A and hCG were measured between 10 3/7 and 13 6/7 weeks gestation on women in the First Trimester Prediction of Adverse Pregnancy Outcome Study. Pearson's correlation coefficient was used to assess the relationships between the markers. Chi-square test was used to assess the relationship between placental volume (dichotomized at the 10th percentile) and BWt < 10th percentile. Women with a multiple gestation, chronic hypertension, pre-existing diabetes mellitus, incomplete pregnancy outcome data, and a pregnancy outcome of delivery less than 37 weeks gestation, preeclampsia or gestational hypertension in the current pregnancy were excluded which left a total of 221 for inclusion in our final analysis.ResultsMean maternal age at recruitment was 34.0 ± 4.9 years. Mean BMI: 23.8 ± 4.6. Mean GA at delivery: 39.4 ± 1.1 weeks. Mean BWt: 3329 ± 421.6 grams. There were 24 cases with BWt < 10th percentile. Women with a placental volume <10th percentile were 3.0 times more likely to have BWt < 10th percentile (95% CI 1.1-8.4).ConclusionsTabled 1Marker CombinationrpPlacental Volume + BWt.18.006Mean UtA RI + BWt.03NSPAPP-A + BWt.18.008hCG + BWt−.06NSPAPP-A + Placental Volume.18.007 Open table in a new tab ObjectiveA number of first trimester ultrasound and maternal serum markers have been proposed to predict intrauterine growth restriction (IUGR). The goal of this study was to determine if placental volume, mean uterine artery resistance index (UtA RI), PAPP-A and total β-hCG (hCG) are associated with birth weight (BWt) in a low risk population. A number of first trimester ultrasound and maternal serum markers have been proposed to predict intrauterine growth restriction (IUGR). The goal of this study was to determine if placental volume, mean uterine artery resistance index (UtA RI), PAPP-A and total β-hCG (hCG) are associated with birth weight (BWt) in a low risk population. Study DesignThree-dimensional placental volume, UtA RI and maternal serum PAPP-A and hCG were measured between 10 3/7 and 13 6/7 weeks gestation on women in the First Trimester Prediction of Adverse Pregnancy Outcome Study. Pearson's correlation coefficient was used to assess the relationships between the markers. Chi-square test was used to assess the relationship between placental volume (dichotomized at the 10th percentile) and BWt < 10th percentile. Women with a multiple gestation, chronic hypertension, pre-existing diabetes mellitus, incomplete pregnancy outcome data, and a pregnancy outcome of delivery less than 37 weeks gestation, preeclampsia or gestational hypertension in the current pregnancy were excluded which left a total of 221 for inclusion in our final analysis. Three-dimensional placental volume, UtA RI and maternal serum PAPP-A and hCG were measured between 10 3/7 and 13 6/7 weeks gestation on women in the First Trimester Prediction of Adverse Pregnancy Outcome Study. Pearson's correlation coefficient was used to assess the relationships between the markers. Chi-square test was used to assess the relationship between placental volume (dichotomized at the 10th percentile) and BWt < 10th percentile. Women with a multiple gestation, chronic hypertension, pre-existing diabetes mellitus, incomplete pregnancy outcome data, and a pregnancy outcome of delivery less than 37 weeks gestation, preeclampsia or gestational hypertension in the current pregnancy were excluded which left a total of 221 for inclusion in our final analysis. ResultsMean maternal age at recruitment was 34.0 ± 4.9 years. Mean BMI: 23.8 ± 4.6. Mean GA at delivery: 39.4 ± 1.1 weeks. Mean BWt: 3329 ± 421.6 grams. There were 24 cases with BWt < 10th percentile. Women with a placental volume <10th percentile were 3.0 times more likely to have BWt < 10th percentile (95% CI 1.1-8.4). Mean maternal age at recruitment was 34.0 ± 4.9 years. Mean BMI: 23.8 ± 4.6. Mean GA at delivery: 39.4 ± 1.1 weeks. Mean BWt: 3329 ± 421.6 grams. There were 24 cases with BWt < 10th percentile. Women with a placental volume <10th percentile were 3.0 times more likely to have BWt < 10th percentile (95% CI 1.1-8.4). ConclusionsTabled 1Marker CombinationrpPlacental Volume + BWt.18.006Mean UtA RI + BWt.03NSPAPP-A + BWt.18.008hCG + BWt−.06NSPAPP-A + Placental Volume.18.007 Open table in a new tab