14C-NaVP and14C-PEV repeated dose study in rat pharmacokinetic study in rats after repeated oral administrations of14C-valproic acid sodium salt and14C-valproic acid pivaloyl oxymethyl ester

M. Bertolino,D. Acerbi,S. Canali,C. Giachetti,G. Poli,P. Ventura,G. Zanolo

European Journal of Drug Metabolism and Pharmacokinetics（1998）

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摘要

The absorption, excretion and tissue distribution of radioactivity after repeated oral equimolar doses of14C-valproic acid sodium salt (NaVP) or14C-valproic acid pivaloyl oxymethyl ester (PEV) was investigated in male rats treated once a day for 14 consecutive days.

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关键词

Valproic acid, Valproic acid pivaloyl oxymethyl ester, radioactivity, tissue distribution, pharmacokinetics

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