基于防突变浓度的新型药动学-药效学-突变选择窗同步模型在临床用药上的指导作用
China Animal Husbandry & Veterinary Medicine（2013）
Abstract
文章综述了抗菌药药动学/药效学(PK/PD)模型的发展,详细阐述新型药动物学/药效学模型在抑制细菌耐药突变上的作用,为合理用药及新药研发提供指导,并指出了临床应用所存在的问题。
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Key words
mutant selection window,resistance,PK/PD model,rational drug administration
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