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Indenone Derivatives:  A Novel Template for Peroxisome Proliferator-Activated Receptor γ (PPARγ) Agonists

Jin Hee Ahn,Mi Sik Shin,Sun Ho Jung,Seung Kyu Kang,Kwang Rok Kim,Sang Dal Rhee,Won Hoon Jung,Sung Don Yang,Seung Jun Kim,Joo Rang Woo,Jeong Hyung Lee,Hyae Gyeong Cheon,Sung Soo Kim

JOURNAL OF MEDICINAL CHEMISTRY（2006）

Cited 128|Views21
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Abstract
Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.
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Key words
pparγ,receptor,proliferator-activated
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