203 ANGIOTENSIN-2 RECEPTORS TYPE 1 AND TYPE 2, NEW PROGNOSTIC FACTORS FOR RENAL CLEAR CELL CARCINOMA?

You have accessJournal of UrologyKidney Cancer: Basic Research II1 Apr 2010203 ANGIOTENSIN-2 RECEPTORS TYPE 1 AND TYPE 2, NEW PROGNOSTIC FACTORS FOR RENAL CLEAR CELL CARCINOMA? Cecile Vigneau, Pierre Bigot, Gregory Verhoest, Florence Jouan, Thibault Dolley-Hitze, Stephanie Mottier, Patrick Le Pogamp, Nathalie Rioux-Leclercq, and Jean-Jacques Patard Cecile VigneauCecile Vigneau Rennes, France More articles by this author , Pierre BigotPierre Bigot Angers, France More articles by this author , Gregory VerhoestGregory Verhoest Rennes, France More articles by this author , Florence JouanFlorence Jouan Rennes, France More articles by this author , Thibault Dolley-HitzeThibault Dolley-Hitze Rennes, France More articles by this author , Stephanie MottierStephanie Mottier Rennes, France More articles by this author , Patrick Le PogampPatrick Le Pogamp Rennes, France More articles by this author , Nathalie Rioux-LeclercqNathalie Rioux-Leclercq Rennes, France More articles by this author , and Jean-Jacques PatardJean-Jacques Patard Rennes, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.260AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Angiotensin-II (ATII) is a growth factor for normal and tumoral cells. It has been recently demonstrated that some cancers as breast cancer over-express angiotensin receptors type 1 (AT1-R), which could be one of the mechanisms for tumor growth. Few is known about ATII receptor expression in human Renal Clear Cell Carcinoma (RCC), although it develops from tubular cells which constituvely highly express both receptors. In this study, AT1-R and AT2-R expressions were quantified in a retrospective series of RCC and tested for their prognostic value. METHODS AT1-R and AT2-R were quantified on tumoral tissues by immunohistochemistry (IHC), western Blot and qRT-PCR. Receptors quantities (proteins or mRNA) were analyzed in relation to Fuhrman grades, metastasis at surgical time and patient progression-free survival. RESULTS Eighty four patients with RCC operated from 2002 to 2006 were included in this study. They were 50 men and 34 women. Mean age at diagnosis was 63.7 (+/- 11.3) years. Three tumors were Fuhrman grade 1, 32 grade 2, 26 grade 3 and 23 grade 4. By IHC, AT1-R and AT2-R were more expressed in Fuhrman grade 4 tumors compared to tumors of lowest grades (p<0.0001). In univariate analysis, TNM Stage, Fuhrman grade (p<0.0001), tumor size (p=0.001), AT1-R and AT2-R expressions were associated with progression-free survival (p=0.001). In multivariate analysis, only AT2-R expression (p=0.006) and T Stage (p=0.000) remained independent predictors for progression-free survival. CONCLUSIONS AT1-R and AT2-R proteins are overexpressed in aggressive RCCs and AT2-R expression is independently associated with progression-free survival. Both receptors are potential new prognostic factors for RCC. Finally, AT1-R or AT2-R blockage could represent a promising therapeutic perspective. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e80-e81 Peer Review Report Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Cecile Vigneau Rennes, France More articles by this author Pierre Bigot Angers, France More articles by this author Gregory Verhoest Rennes, France More articles by this author Florence Jouan Rennes, France More articles by this author Thibault Dolley-Hitze Rennes, France More articles by this author Stephanie Mottier Rennes, France More articles by this author Patrick Le Pogamp Rennes, France More articles by this author Nathalie Rioux-Leclercq Rennes, France More articles by this author Jean-Jacques Patard Rennes, France More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...