A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors.
Bioorganic & Medicinal Chemistry Letters（2006）
Abstract
Tenfold improvement of the oral bioavailability of TNF484 with the help of cassette-dosing is described.
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Key words
TNFα,TACE,MMP,Metalloproteinase,Dual,Inhibitor,Pharmacokinetics,Cassette-dosing,Bioavailability,Oral,Clearance,Absorption,Rheumatoid arthritis,Trocade,TNF484,Claisen–Ireland rearrangement
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