Protection Mechanism of Angiotensin Inhibitors on Cardiac Injury in Rats with Diabetes

Objective To study the protection mechanism of angiotensin inhibitors on cardiac injury in rats with type 2 diabetes.Methods Male Sprague Dawley(SD) rats were divided into two groups,high-sugar high-fat fed diabetic group,with a small dose(40 mg / kg) intraperitoneal injection of streptozotocin induced rat model of type 2 diabetes to become;control group of ordinary diet,intraperitoneal injection of citrate buffer;Diabetic group and then divided into two groups,one group was given normal saline(0.5mL/(kg· d)),one group was given ramipril solution(1mg/(kg· d)),eight weeks after gavage,test heart function The parameters and measured plasma and cardiac tissue angiotensin Ⅱ(Ang Ⅱ) content of myocardial Caspase-3 activity,serum creatine kinase(CK-MB),cardiac troponin Ⅰ(cTnI) Content of myocardial superoxide dismutase(SOD),malondialdehyde(MDA) content.Results The Results showed that compared with the control group,type 2 diabetes,plasma and myocardium Ang Ⅱ was significantly higher in heart function LVSP,dp/dtmax decreased,LVEDP increased significantly,Caspase-3,CK-MB,cTn1,MDA were significantly increased,SOD significantly decreased;and intragastric saline group,fed the blood ramipril award and tissue Ang Ⅱ were significantly decreased heart function dp/dtmax increased significantly,LVEDP decreased,Caspase-3,CK-MB,cTn1,MDA were significantly decreased,SOD significantly increased.Conclusion Angiotensin Ⅱ increased in the diabetes high glucose and lipid-mediated impaired heart function,myocardial cell damage,through inhibition of Ang Ⅱ may be due to type 2 diabetes,heart damage play a protective role.