COX-2 expression in chondrosarcoma: A role for celecoxib treatment?

Y.M. Schrage,I. Machado,D. Meijer,I. Briaire-de Bruijn,B.E. van den Akker,A.H.M. Taminiau,T. Kalinski, A. Llombart-Bosch,J.V.M.G. Bovée

European Journal of Cancer（2010）

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摘要

Chondrosarcomas are resistant to conventional chemo- and radiotherapy. A subset of chondrosarcomas arises secondarily in the benign tumour syndromes enchondromatosis (EC) and multiple osteochondromas (MO), and prevention of tumour development would greatly improve prognosis. We therefore investigated the effect of selective COX-2 inhibition on chondrosarcoma growth.

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关键词

Bone tumours,Chondrosarcoma,COX-2 inhibition,Therapy,Xenograft

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