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N-烟酰基-L-天门冬氨酸的致突变性检测

Xiao-qiu LIU,Fei GU,Rong-xian WANG,Mei-jia LI,Ying HAN

Carcinogenesis,Teratogenesis & Mutagenesis（2007）

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Abstract
背景与目的:研究N-烟酰基-L-天门冬氨酸遗传毒性,为临床安全用药提供理论依据.材料与方法:采用Ames试验、中国仓鼠卵巢细胞(CHO细胞)染色体畸变试验及小鼠微核试验对N-烟酰基-L-天门冬氨酸进行致突变性研究.结果:Ames试验中加S9与不加S9混合液的各剂量组回变菌落数与阴性对照无明显差别,且无剂量-效应关系.小鼠骨髓细胞微核率及CHO细胞染色体畸变率与阴性对照组比较,差别也无统计学意义(P＞0.05).结论:在本实验条件下,N-烟酰基山天门冬氨酸无致突变作用.
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Key words
micronucleus,Ames test,N-Nicotinyl-aspartic acid,chromosome aberration
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