Expression and clinical significance of MMP-3 and p53 in mammary carcinoma

Objective To study the significance of MMP-3 and p53 expression in patients with mammary carcinoma.Methods The expression of MMP-3 and p53 were detected by immunohistochemical S-P in 58 mammary infiltration duct carcinoma tissue samples and their clinical data were statistically analysed.Results In 58 mammary carcinoma tissue samples,the expression of MMP-3 was 44.83% and the expression of p53 was 37.93%.The expression of MMP-3 was correlated significantly with lymph node metastasis,P0.05;The expression of p53 was correlated significantly with the size of cancer,P0.05.Conclusions The expression of MMP-3,p53 can be taken as the biological marker of prognosis and postoperative comprehensive treatment of breast cancer.