URIC ACID IN URINE AND SUBCLINICAL INFLAMMATION IN THE HYPERTENSIVE PATIENTS: PP.12.461:

Objective: Some authors hypotized that cytokines may increase the uric acid production and through the enhancement of xanthine oxidase activity the reactive oxygen species mediated cell damage and the promotion of apoptosis in hypertensive animals. The aim of our study was to investigate association uric acid in urine (UAU) and subclinical inflammation markers in the hypertensive patients. Design and Method: 58 EH pts (46 M, 12 F) grade 1 or 2, av. age 44,4 ± 1,7 years; without antyhypertensive therapy for 2 weeks before study. Patients with acute inflammatory diseases, not earlier than 2 months were included in study. Serum uric acid (SUA) and UAU (1,48–4,43 mmol/day) was defined by a UF method on the uricase selective analyzer. High-sensitivity C-reactive protein (CRP) and Uric albumin excretion (UAE) was defined by a turbidimetry method. 24 hour blood pressure monitoring (24-h BPM) was carried out by Meditech (Hungary). The statistical analysis was carried out by nonparametric methods of Spearman and Mann-Whitney with STATISTICA 6. The data is presented as M ± m. Results: According UAU the all EH pts was divided into the two groups. The average levels of CRP, SUA and UAU were considerably higher in the increase UAU pts (group I) compared to normal UAU pts (group II) (Tab). TableAlso, in the increase UAU group was found significant association between CRP and 24-h SBP (r = 0,67; p = 0,001). The same association was not demonstrated in the normal UAU group. Conclusion: Determination of the increased levels UAU might be the early renal damage marker in the hypertensive patients.