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Endovascular photodynamic therapy with aminolaevulinic acid prevents balloon induced intimal hyperplasia and constrictive remodelling.

E E E Gabeler,R van Hillegersberg,R G Statius van Eps,W Sluiter,P Mulder,H van Urk

European Journal of Vascular and Endovascular Surgery（2002）

Cited 19|Views9
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Abstract
Background and Objective: intimal hyperplasia (IH) and constrictive remodelling are important causes of restenosis following endovascular interventions, such as percutaneous transluminal angioplasty. Photodynamic therapy (PDT) with 5-aminolaevulinic (ALA) may prevent restenosis by cellular depletion and the elimination of cholinergic innervation.
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Key words
ALA, Endovascular PDT, IH, Light dosimetry, Cholinergic innervation, Remodelling, Stenosis model
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