Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A2A receptor antagonists

Novel thiazolotriazolopyrimidine derivatives were (23–33) designed and synthesized to evaluate their potential adenosine A2A receptor (A2AR) antagonists activity. Docking simulation results showed that thiazolotriazolopyrimidine derivatives (23–33) and SCH58261, a standard A2AR antagonist shared a similar binding motif inside the transmembrane (TM) region and extracellular loops of the human A2AR Our results showed that the compound 25 (R=C4H9) possessed reasonably good affinity (Ki=0.12nM) and high selectivity with A2A receptor (A2A/A1=1288).