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Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists?

Alexander Titz,John Patton,André M Alker,Michele Porro,Oliver Schwardt,Michael Hennig,Eric Francotte,John Magnani,Beat Ernst

Bioorganic & Medicinal Chemistry（2008）

Cited 6|Views6
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Abstract
For the pre-organization of the acid orientation in the bioactive conformation, the selectin antagonists 7 containing (R)- and (S)-adamantyl-lactic acid were synthesized and biologically evaluated.
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Key words
E-selectin,Sialyl Lewisx,Pre-organization,Adamantane
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