丙酮酸钠液对烫伤休克大鼠肾血管通透性的影响
China Medical Engineering（2011）
Abstract
目的 观察丙酮酸钠对烫伤休克大鼠肾通透性的影响.方法 采用50%TBSAⅢ度烫伤大鼠模型,大鼠随机分为假烫组、烫伤组、氯化钠组和丙酮酸钠组,每组6只.应用伊文斯蓝法测定伤后4h肾组织通透性及含水量的变化,检测血肌酐(Cr)及血细胞压积(HCT)变化.结果 烫伤后4h单纯烫伤组,氯化钠组肾伊文斯兰含量、Cr、HCT及含水量较假烫组明显增加(P＜0.05),丙酮酸钠组伊文斯兰含量、Cr、HCT及含水量较单纯烫伤组、氯化钠组明显降低(P＜0.05),而与假烫组无明显统计学差异.结论 丙酮酸钠能明显减轻烧伤早期血管通透性的增加,有助于烧伤后休克及并发症的防治.
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Key words
vascular permealbility,burn shock,pyruvate,kidney
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