Comparative effects of five bisphosphonates on apoptosis of macrophage cells in vitro
Biochemical Pharmacology(2007)
摘要
Bisphosphonates (BPs) inhibits bone resorption by reducing osteoclastic activity; they induce osteoclast apoptosis. Pathophysiology of prostheses loosening is complex and implies an inflammatory reaction secondary to the phagocytosis of wear debris by macrophages with a secondary increased bone resorption by osteoclasts. BPs inhibit proliferation and cause cell death in macrophages by induction of apoptosis. We have used mouse macrophage-like J774.1 cells to evaluate the effects of five BPs.
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关键词
Bisphosphonates,Apoptosis,Necrosis,Macrophage,Flow cytometry
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