转FBP7-iaaM基因棉籽表达蛋白的小鼠急性经口毒性研究
Journal of Environment and Health(2012)
Abstract
目的探讨转FBP7-iaaM基因棉籽表达蛋白的急性经口毒性。方法选择体重18~22 g的SPF级健康昆明小鼠16只,雌雄各半。禁食16 h后,以iaaM基因表达蛋白2 000 mg/kg剂量一次经口灌胃染毒,连续观察2周。结果该蛋白染毒后未见明显中毒症状,两周内未出现死亡。结论 iaaM基因表达蛋白对小鼠急性经口毒性LD50>2 000 mg/kg。
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Key words
Target protein,Acute oral toxicity,Mice,FBP7-iaaM gene
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