Diagnosis Of Ovarian-Cancer With Radiolabeled Antibodies
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology(1989)
Abstract
This paper reviews the current methods for radiolabelling monoclonal antibodies with particular emphasis on radiometals useful for radioimmunoscintigraphy. The discussion, however, is equally applicable to therapeutic radionuclides. The advantages and the pitfalls of the various techniques are critically evaluated. Both direct labeling methods, as well as indirect methods using the bifunctional chelating agent approach, are covered. Recent work on the development and synthesis of new and more specific chelating agents, including the approach of utilizing rigid polyaminocarboxylates, is described. Preliminary promising results with these newer generation chelating agents are presented.
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Key words
Antibody Engineering,Cancer Treatment,Radioimmunotherapy
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