检测leptin、IGF-Ⅰ、IGF-BP3、E2、T在肥胖儿发育中的临床意义

Journal of Radioimmunology(2008)

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Abstract
目的:研讨学龄前肥胖和非肥胖儿童的瘦素与内分泌激素水平. 方法:检测(3~6)?22例单纯性肥胖儿童与61例非肥胖儿童的瘦素(leptin)、胰岛素样生长因子Ⅰ(IGF-Ⅰ)、胰岛素样生长因子结合蛋白-3(IGF-BP3)、雌二醇(E2)、睾酮(T)水平. 结果:肥胖儿童的leptin、IGF-Ⅰ.IGF-BP3、E2水平均显著高于各自非肥胖儿童组(P均<0.01).T水平两组间无显著差别(P>0.05). 结论:学龄前单纯性肥胖儿童存在leptin抵抗和内分泌代谢紊乱,检测leptin、IGF-Ⅰ、IGF-BP3、E2、T对单纯性肥胖症的早期干预有着重要的临床意义.
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Key words
T,preschool children,leptin,simple obesity,IGF-I,IGF-BP_3,E_2
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