Metabolites of Ebrotidine, a New hfe-Receptor Antagonist, in Human Urine
Journal of Pharmaceutical Sciences(1994)
摘要
Ebrotidine is a new H-2-receptor antagonist which exhibits a remarkable ability for gastric mucosal protection. A preliminary metabolic pathway for this compound was proposed and the hypothetic metabolites were synthesized. The presence of ebrotidine and its metabolites ebrotidine S-oxide and 4-bromobenzenesulfonamide in human urine has been confirmed by HPLC separation and spectroscopic characterization of the collected fractions by FT-IR and H-1 NMR. Ebrotidine S,S-dioxide has been identified by HPLC using diode-array detection.
更多查看译文
关键词
ebrotidine,metabolites,human urine,hfe-receptor
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要