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3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.

Ramani R Ranatunge,Richard A Earl,David S Garvey,David R Janero,L Gordon Letts,Allison M Martino,Madhavi G Murty,Stewart K Richardson,David J Schwalb,Delano V Young,Irina S Zemtseva

Bioorganic & Medicinal Chemistry Letters（2005）

Cited 57|Views12
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Abstract
The synthesis of a series of novel 3-(2-methoxytetrahydrofuran-2-yl)pyrazoles and their in vitro cyclooxygenase-2 (COX-2) inhibitory activity in human whole blood (HWB) are reported.
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Key words
Cyclooxygenase-2 (COX-2),Pyrazole,Tetrahydrofuran-2-yl
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