Adenosine dialdehyde analogs I: Regioselective synthesis of adenosine monoaldehydes

John P. Neenan,Sumittada M. Opitz,Charles L. Cooke,Michael A. Ussery,Terence C. Morrill,Linda M. Eckel

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1996）

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摘要

Selective borohydride reduction of adenosine dialdehyde (1) gave the known adenosine 2'-monoaldehyde (2). Reaction of 1 with N,N'-diphenylethylenediamine, followed by reduction and deblocking gave adenosine 3'-monoaldehyde (5), a new compound. Unlike 2, compound 5 inhibited S-AdoHcy hydrolase and showed antiviral activity in vitro. Copyright (C) 1996 Elsevier Science Ltd

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